You'd have to give up the line in in the rear or wire in an RCA switch (I recommend an auto-sensing unit) or have that plug sticking out, mucking up the face, which, you may as well just use a standard stereo-to-stereo cable instead of going through wires.
Depending on whether it defaults to on or not, you'd have to mount it so you could turn it on.
You wouldn't be able to skip or pause or anything through the head unit either, so really you're going to have to have your audio device accessible to change the songs, and push something to get it to work. Really, I'd go with a simple stereo plug if you're going to have to turn the device on and still control everything through the audio device.