alt wine? check your grounds
does your car have a factory amp?
does your car have a aftermarket 4ch amp?
make sure that there are no high current power wires running too close to signal cables
make sure that all your ground are in the same spot
make sure that your battery has a good ground clean of any corrosion
make sure that your motor has a good ground, not loose or no corrosion
make sure that your gains are not turned up too high
if you dont have any amps there is either a groung issue with the radio or there is somthing wrong with the radio
oh yea, it helps to know what kind of vehicle it is in and what parts where used for the install, and what components are hooked up in the system, and what stereo option the car had (bose, monson, mach, HK, Mark Levinston...) and anything else you might think could be helpfull