Here's the issue you're going to face with a large USB or SD drive.
The Pioneer head unit must index the music folders each time on start up. The larger the files, the longer it will take. I had a 64 G drive that took nearly two minutes before it was ready to play, and it won't index while you're using another audio source.
As previously noted, either the SD or USB drives must be formatted in FAT32, exFat will not work. Windows won't natively format a drive larger than I believe 32 G as anything but exFAT. You'll have to get a third party program to do it.
One other point. I've heard of sort issues with USB and SD drives. It's kinda hard to find a song or album if you've gotta go through each file to find it.
I finally stepped to the plate and got an iPod Classic 160 G which solved my problem.