first off yes it will be different from speaker to speaker and person to person. I have not yet found my perfect setting.

My set up is D3, Kicker DS68 door speakers with kenwood 4X40rms amp, Two 10" Kicker CVRs under the back seat running them at 4OHMs with a Rockforfosgate 325.1 @ 400RMS@2 OHMS

 

My settings are

HPF on at 120 i think

Music

EQs are

Low-80Hz-+4dB-Q Wide2

Mid-1KHz-+6dB-Q Wide2

High-10KHz-+6dB-Q Wide1