I just installed a 8200nex into my car. I was somewhat surprised to see that the Pioneer "power" plug is the same 2x8 pin rectangular plug that I'm used to from 15 year old single DIN headunits.
So the W8500NEX still uses this plug, but there are other options as well.
To be clear, the "power plug" serves many functions. First, it supplies power to the unit - ground wire, constant 12v power (for preserving settings and memory), switched 12v power (so the unit turns on/off when you turn your key), and illumination setting (so the display brightness matches your interior brightness setting). Those are the 4 main power wires, and the rest of the wires in the 16pin plug are for speaker signals, remote amp turn-on, and etc.
In the newer models, the power plug also has wires for the vehicle speed signal (VSS), reverse signal, and parking brake signal. The VSS is for GPS function, which the 8500nex has, but your other model may not. The reverse signal is for back-up camera option, which your older model may not have supported. And then the parking brake wire is for confirming the vehicle is parked when you want to watch video content (DVD, HDMI input, etc).
So, in short, the plug from your old unit will fit into the new one, but you may have to add a few wires or tweak some things.